Purpose We recently demonstrated that a polymorphism in codons 22 and 23 of the glucocorticoid receptor gene is associated with relative glucocorticoid resistance, greater insulin sensitivity, and lower total and low-density lipoprotein cholesterol levels. In the present study, we investigated whether the ER22/23EK polymorphism is associated with survival, cholesterol levels, and two predictors of mortality: serum C-reactive protein and interleukin 6 levels. Methods We studied 402 men (mean [± SD] age, 77.8 ± 3.6 years). C-reactive protein was measured by a highly sensitive method using a latex-enhanced immunoephelometric assay. Interleukin 6 was determined by a commercially available immulite assay. Results After a follow-up of 4 years, 73 (19%) of 381 noncarriers died, while none of the 21 ER22/23EK carriers had died (P = 0.03). C-reactive protein levels were about 50% lower in ER22/23EK carriers (P = 0.01). There were no differences in interleukin 6 levels. Conclusion Carriers of the ER22/23EK polymorphism have better survival than noncarriers, as well as lower C-reactive protein levels.

dx.doi.org/10.1016/j.amjmed.2004.01.027, hdl.handle.net/1765/60182
The American Journal of Medicine
Department of Reproduction and Development

van Rossum, E.F.C, Feelders, R.A, van den Beld, A.W, Uitterlinden, A.G, Janssen, J.A.M.J.L, Ester, W.A, … Lamberts, S.W.J. (2004). Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men. The American Journal of Medicine, 117(3), 158–162. doi:10.1016/j.amjmed.2004.01.027