2006-11-01
Donor-Reactive Cytokine Production After HLA-Identical Living Related Kidney Transplantation: A Protein-Array Analysis
Publication
Publication
Transplantation Proceedings , Volume 38 - Issue 9 p. 2825- 2827
In the present pilot study, we investigated which proteins are produced after donor stimulation of peripheral blood mononuclear cells from recipients of HLA-identical living related kidney transplant. We used a protein-array analysis to determine cytokines, chemokines, and growth factors in supernatant from donor-stimulated mixed lymphocyte reaction cultures. Autologous cultures were considered to be negative controls. In 38 out of 42 proteins (90%), the donor response was higher compared with the autologous response. Therefore, we concluded that even after HLA-identical living related kidney transplantation we could measure a donor-reactive response, which we assumed was directed toward minor histocompatibility or non-HLA antigens.
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| doi.org/10.1016/j.transproceed.2006.08.183, hdl.handle.net/1765/60467 | |
| Transplantation Proceedings | |
| Organisation | Department of Internal Medicine |
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Gerrits, J., van de Wetering, J., Weimar, W., & van Besouw, N. (2006). Donor-Reactive Cytokine Production After HLA-Identical Living Related Kidney Transplantation: A Protein-Array Analysis. Transplantation Proceedings, 38(9), 2825–2827. doi:10.1016/j.transproceed.2006.08.183 |
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