2005-04-01
Insertion/deletion polymorphism of the ACE gene and adherence to ACE inhibitors
Publication
Publication
British Journal of Clinical Pharmacology , Volume 59 - Issue 4 p. 483- 485
Aims: We investigated whether the insertion/deletion (I/D) polymorphism of the ACE gene modified the adherence to ACE inhibitors as measured by the discontinuation of an ACE inhibitor, or addition of another antihypertensive drug. Methods: This was a cohort study among 239 subjects who started ACE inhibitor therapy. A Cox proportional hazard model was used to calculate relative risk (RR). Results: During follow-up there was no significant difference between subjects with the DD, ID or II genotype (DD vs II; RR= 1.17, 95%CI: 0.78, 1.77 and ID vs II; RR = 1.06, 95%CI: 0.73, 1.55) in adherence. Conclusions: The I/D polymorphism of the ACE gene does not influence the adherence to ACE inhibitors.
| Additional Metadata | |
|---|---|
| , , | |
| doi.org/10.1111/j.1365-2125.2004.02332.x, hdl.handle.net/1765/60477 | |
| British Journal of Clinical Pharmacology | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
|
Schelleman, H., Klungel, O., van Duijn, C., Witteman, J., Hofman, A., de Boer, A., & Stricker, B. (2005). Insertion/deletion polymorphism of the ACE gene and adherence to ACE inhibitors. British Journal of Clinical Pharmacology, 59(4), 483–485. doi:10.1111/j.1365-2125.2004.02332.x |
|