Aims: We investigated whether the insertion/deletion (I/D) polymorphism of the ACE gene modified the adherence to ACE inhibitors as measured by the discontinuation of an ACE inhibitor, or addition of another antihypertensive drug. Methods: This was a cohort study among 239 subjects who started ACE inhibitor therapy. A Cox proportional hazard model was used to calculate relative risk (RR). Results: During follow-up there was no significant difference between subjects with the DD, ID or II genotype (DD vs II; RR= 1.17, 95%CI: 0.78, 1.77 and ID vs II; RR = 1.06, 95%CI: 0.73, 1.55) in adherence. Conclusions: The I/D polymorphism of the ACE gene does not influence the adherence to ACE inhibitors.

ACE gene, ACE inhibitors, Polymorphism,
British Journal of Clinical Pharmacology
Erasmus MC: University Medical Center Rotterdam

Schelleman, H, Klungel, O.H, van Duijn, C.M, Witteman, J.C.M, Hofman, A, de Boer, A.C, & Stricker, B.H.Ch. (2005). Insertion/deletion polymorphism of the ACE gene and adherence to ACE inhibitors. British Journal of Clinical Pharmacology, 59(4), 483–485. doi:10.1111/j.1365-2125.2004.02332.x