Fibrinogen heterogeneity: Inherited and noninherited

Purpose of review: Many noninherited or inherited variations have been described in fibrinogen and they may affect the different functions of fibrinogen. Recent findings: A number of the acquired variations in fibrinogen affect the properties of the fibrinogen molecule, such as the conversion rate to fibrin and/or the characteristics of the fibrin clot. Also, genetic polymorphisms are known that can affect the function of the fibrinogen molecule. In addition, some other genetic variants are associated with plasma levels of fibrinogen and with the increase of fibrinogen levels during an acute-phase reaction. Summary: In this review the authors discuss the noninherited and inherited variations of fibrinogen and the clinical implications (e.g. when determining the risk of cardiovascular disease).

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