Role of cytokines in myocardial ischemia and reperfusion
Mediators of Inflammation , Volume 6 - Issue 3 p. 175- 183
Mediators of myocardial in ammation, predomi- nantly cytokines, have for many years been implicated in the healing processes after infarction. In recent years, however, more attention has been paid to the possibility that the in ammation may result in deleterious complications for myo- cardial infarction. The proin ammatory cyto- kines may mediate myocardial dysfunction associated with myocardial infarction, severe con- gestive heart failure, and sepsis. A growing body of literature suggests that in ammatory mediators could play a crucial role in ischemia ±reperfusion injury. Furthermore, ischemia ±reperfusion not only results in the local transcriptional and translational upregulation of cytokines but also leads to tissue in ltration by in ammatory cells. These in ammatory cells are a ready source of a variety of cytokines which could be lethal for the cardiomyocytes. At the cellular level it has been shown that hypox ia causes a series of well documented changes in cardiomyocytes that in- cludes loss of contractility, changes in lipid metabolism and subsequent irreversible cell membrane damage leading to cell death. For instance, hypox ic cardiomyocytes produce interleukin-6 (IL-6) which could contribute to the myocardial dysfunction observed in ischemia ± reperfusion injury. Ischemia followed by reperfu- sion induces a number of other multi-potent cytokines, such as IL-1, IL-8, tumor necrosis factor-a (TNF-a), transforming growth factor-b1 (TGF-b1) as well as an angiogenic cytokine/ growth factor, vascular endothelial growth factor (VEGF), in the heart. Intrestingly, these multi- potent cytokines (e.g. TNF-a) may induce an adaptive cytoprotective response in the reperfused myocardium. In this review, we have in- cluded a number of cytokines that may contribute to ventricular dysfunction and/or to the cytoprotective and adaptive changes in the reperfused heart.
|Cytokine, Heart, IL-1, IL-6, Ischemia-reperfusion, TGF-β, TNF-α|
|Mediators of Inflammation|
|Organisation||Department of Pharmacology|
Sharma, H.S, & Das, D.K. (1997). Role of cytokines in myocardial ischemia and reperfusion. Mediators of Inflammation (Vol. 6, pp. 175–183). doi:10.1080/09629359791668