Understanding the mechanisms by which estrogens affect cardiovascular disease risk, including the role of variation in the gene for estrogen receptor a (ESR1), may be key to new treatment strategies. We investigated whether the CC genotype at ESR1 c.454-397T>C is associated with increased risk among men. Study of more than 7000 whites in 5 cohorts from 4 countries provided evidence that genotype CC, present in roughly 20% of individuals, is a risk factor for nonfatal acute myocardial infarction (odds ratio=1.44; P<0.0001), after adjustment for established cardiovascular risk factors. After exclusion of younger subjects from 2 cohorts, because of age interaction, the odds ratio increased (to 1.63).

Estrogen receptor, Genetics, Myocardial infarction, Risk factors
dx.doi.org/10.1161/01.RES.0000210578.62102.a6, hdl.handle.net/1765/60733
Circulation Research
Erasmus MC: University Medical Center Rotterdam

Shearman, A.M, Cooper, J, Kotwinski, P.J, Miller, G.J, Humphries, S.E, Ardlie, K.G, … Housman, D.E. (2006). Estrogen receptor α gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts. Circulation Research, 98(5), 590–592. doi:10.1161/01.RES.0000210578.62102.a6