2006-03-01
Estrogen receptor α gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts
Publication
Publication
Circulation Research , Volume 98 - Issue 5 p. 590- 592
Understanding the mechanisms by which estrogens affect cardiovascular disease risk, including the role of variation in the gene for estrogen receptor a (ESR1), may be key to new treatment strategies. We investigated whether the CC genotype at ESR1 c.454-397T>C is associated with increased risk among men. Study of more than 7000 whites in 5 cohorts from 4 countries provided evidence that genotype CC, present in roughly 20% of individuals, is a risk factor for nonfatal acute myocardial infarction (odds ratio=1.44; P<0.0001), after adjustment for established cardiovascular risk factors. After exclusion of younger subjects from 2 cohorts, because of age interaction, the odds ratio increased (to 1.63).
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doi.org/10.1161/01.RES.0000210578.62102.a6, hdl.handle.net/1765/60733 | |
Circulation Research | |
Organisation | Erasmus MC: University Medical Center Rotterdam |
Shearman, A., Cooper, J., Kotwinski, P., Miller, G., Humphries, S., Ardlie, K., … Housman, D. (2006). Estrogen receptor α gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts. Circulation Research, 98(5), 590–592. doi:10.1161/01.RES.0000210578.62102.a6 |