2001-12-01
Serum thrombopoietin levels in relation to disease status in patients with immune thrombocytopenic purpura
Publication
Publication
British Journal of Haematology , Volume 115 - Issue 4 p. 1004- 1006
Pre- and post-treatment serum thrombopoietin (TPO) concentration was measured in 35 patients with immune thrombocytopenic purpura (ITP). Mean post-treatment levels were significantly lower (P = 0.02) than pretreatment and not different for treatment modality. No significant correlation between pre- or post-treatment TPO and platelet counts was demonstrable (R = -0.325, P = 0.056 and R = -0.227, P = 0.190 respectively). In patients with very low platelet counts (≤ 20 × 109/l), pretreatment serum TPO was significantly higher than in patients with higher counts (P = 0.033). The logarithm of the platelet turnover rate, measured in 15 patients, correlated with pretreatment TPO levels (R = 0.64). These findings suggest a contributory role for TPO in the mechanism of ITP.
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| doi.org/10.1046/j.1365-2141.2001.03184.x, hdl.handle.net/1765/60792 | |
| British Journal of Haematology | |
| Organisation | Department of Gynaecology & Obstetrics |
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Kappers-Klunne, M., de Haan, M., Struijk, P., & van Vliet, H. (2001). Serum thrombopoietin levels in relation to disease status in patients with immune thrombocytopenic purpura. British Journal of Haematology, 115(4), 1004–1006. doi:10.1046/j.1365-2141.2001.03184.x |
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