Pre- and post-treatment serum thrombopoietin (TPO) concentration was measured in 35 patients with immune thrombocytopenic purpura (ITP). Mean post-treatment levels were significantly lower (P = 0.02) than pretreatment and not different for treatment modality. No significant correlation between pre- or post-treatment TPO and platelet counts was demonstrable (R = -0.325, P = 0.056 and R = -0.227, P = 0.190 respectively). In patients with very low platelet counts (≤ 20 × 109/l), pretreatment serum TPO was significantly higher than in patients with higher counts (P = 0.033). The logarithm of the platelet turnover rate, measured in 15 patients, correlated with pretreatment TPO levels (R = 0.64). These findings suggest a contributory role for TPO in the mechanism of ITP.

Immune, Platelet kinetics, Purpura, Thrombocytopenia, Thrombopoietin,
British Journal of Haematology
Department of Gynaecology & Obstetrics

Kappers-Klunne, M.C, de Haan, M, Struijk, P.C, & van Vliet, H.H.D.M. (2001). Serum thrombopoietin levels in relation to disease status in patients with immune thrombocytopenic purpura. British Journal of Haematology, 115(4), 1004–1006. doi:10.1046/j.1365-2141.2001.03184.x