Local adenoviral gene transfer can be performed by means of isolated hepatic perfusion (IHP). This methodology is a very effective and safe way to deliver adenoviral vectors. We studied the immune response after IHP, A decreased neutralising antibody formation was observed, offering possibilities for further research in the field of gene therapy in isolated perfusion settings.

Additional Metadata
Keywords Adenovirus, Antibodies, Gene therapy, Liver perfusion
Persistent URL dx.doi.org/10.1038/sj.bjc.6602151, hdl.handle.net/1765/60913
Journal British Journal of Cancer
Citation
van Etten, B, Eggermont, A.M.M, Aan de Wiel-Ambagtsheer, G, van Tiel, S.T, & ten Hagen, T.L.M. (2004). Impaired neutralising antibody formation and high transduction efficacy after isolated hepatic perfusion with adenoviral vectors. British Journal of Cancer, 91(8), 1610–1613. doi:10.1038/sj.bjc.6602151