Based on blood and cerebrospinal fluid samples collected in a full-term neonate, the penetration of tramadol in the central nervous system is described. Following intravenous administration of tramadol, a lag time of about 4 h was observed until full blood-brain equilibration was achieved. This pharmacokinetic observation is in line with a recent pharmacodynamic evaluation of the central opioid effects of tramadol in adults.

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Keywords CSF pharmacokinetics, Neonate, Pain, Pharmacodynamics, Tramadol
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Journal European Journal of Clinical Pharmacology
Allegaert, K.M, de Hoon, J.N, Verbesselt, R, Devlieger, H, & Tibboel, D. (2005). Tramadol concentrations in blood and in cerebrospinal fluid in a neonate. European Journal of Clinical Pharmacology, 60(12), 911–913. doi:10.1007/s00228-004-0872-7