2005-02-01
Tramadol concentrations in blood and in cerebrospinal fluid in a neonate
Publication
Publication
European Journal of Clinical Pharmacology , Volume 60 - Issue 12 p. 911- 913
Based on blood and cerebrospinal fluid samples collected in a full-term neonate, the penetration of tramadol in the central nervous system is described. Following intravenous administration of tramadol, a lag time of about 4 h was observed until full blood-brain equilibration was achieved. This pharmacokinetic observation is in line with a recent pharmacodynamic evaluation of the central opioid effects of tramadol in adults.
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| doi.org/10.1007/s00228-004-0872-7, hdl.handle.net/1765/60943 | |
| European Journal of Clinical Pharmacology | |
| Organisation | Department of Pediatric Surgery |
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Allegaert, K., de Hoon, J. N., Verbesselt, R., Devlieger, H., & Tibboel, D. (2005). Tramadol concentrations in blood and in cerebrospinal fluid in a neonate. European Journal of Clinical Pharmacology, 60(12), 911–913. doi:10.1007/s00228-004-0872-7 |
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