Based on blood and cerebrospinal fluid samples collected in a full-term neonate, the penetration of tramadol in the central nervous system is described. Following intravenous administration of tramadol, a lag time of about 4 h was observed until full blood-brain equilibration was achieved. This pharmacokinetic observation is in line with a recent pharmacodynamic evaluation of the central opioid effects of tramadol in adults.

CSF pharmacokinetics, Neonate, Pain, Pharmacodynamics, Tramadol,
European Journal of Clinical Pharmacology
Department of Pediatric Surgery

Allegaert, K.M, de Hoon, J.N, Verbesselt, R, Devlieger, H, & Tibboel, D. (2005). Tramadol concentrations in blood and in cerebrospinal fluid in a neonate. European Journal of Clinical Pharmacology, 60(12), 911–913. doi:10.1007/s00228-004-0872-7