2013-07-23
Dopaminergic Neuronal Imaging in Genetic Parkinson's Disease: Insights into Pathogenesis
Publication
Publication
PLoS ONE , Volume 8 - Issue 7
Objectives:To compare the dopaminergic neuronal imaging features of different subtypes of genetic Parkinson's Disease.Methods:A retrospective study of genetic Parkinson's diseases cases in which DaTSCAN (123I-FP-CIT) had been performed. Specific non-displaceable binding was calculated for bilateral caudate and putamen for each case. The right:left asymmetry index and striatal asymmetry index was calculated.Results:Scans were available from 37 cases of monogenetic Parkinson's disease (7 glucocerebrosidase (GBA) mutations, 8 alpha-synuclein, 3 LRRK2, 7 PINK1, 12 Parkin). The asymmetry of radioligand uptake for Parkinson's disease with GBA or LRRK2 mutations was greater than that for Parkinson's disease with alpha synuclein, PINK1 or Parkin mutations.Conclusions:The asymmetry of radioligand uptake in Parkinsons disease associated with GBA or LRRK2 mutations suggests that interactions with additional genetic or environmental factors may be associated with dopaminergic neuronal loss.
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| doi.org/10.1371/journal.pone.0069190, hdl.handle.net/1765/61295 | |
| PLoS ONE | |
| Organisation | Department of Clinical Genetics |
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McNeill, A., Wu, R.-M., Tzen, K.-Y., Aguiar, P., Arbelo, J., Barone, P., … Schapira, A. (2013). Dopaminergic Neuronal Imaging in Genetic Parkinson's Disease: Insights into Pathogenesis. PLoS ONE, 8(7). doi:10.1371/journal.pone.0069190 |
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