Anti-Müllerian hormone (AMH) is expressed after birth in the ovary in the granulosa cells of healthy, small growing follicles. We have shown that AMH affects two important regulatory steps during folliculogenesis. At initial recruitment, AMH inhibits recruitment of primordial follicles into the growing pool, while at cyclic recruitment AMH lowers the FSH-sensitivity of follicles. In these ways, AMH plays an important role in regulation of ovarian follicle growth. AMH serum level is a strong candidate marker for ovarian reserve in women. In normo-ovulatory women, AMH serum levels correlated strongly with the number of antral follicles. In addition, AMH is a strong predictor for the number of oocytes retrieved in patients undergoing IVF treatment. The convenience of determination and its relative stable expression during the menstrual cycle indicate that further validation of the use of serum AMH is recommended as a clinical measure of ovarian reserve.

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Keywords AMH, Follicle, Ovarian ageing, Ovarian reserve, Ovary
Persistent URL dx.doi.org/10.1016/j.mce.2003.09.024, hdl.handle.net/1765/61563
Journal Molecular and Cellular Endocrinology
Citation
Gruijters, M.J.G, Visser, J.A, Durlinger, A.L.L, & Themmen, A.P.N. (2003). Anti-Müllerian hormone and its role in ovarian function. In Molecular and Cellular Endocrinology (Vol. 211, pp. 85–90). doi:10.1016/j.mce.2003.09.024