Discrepant effects of human interferon-gamma on clinical and immunological disease parameters in a novel marmoset model for multiple sclerosis
Journal of Neuroimmune Pharmacology , Volume 7 - Issue 1 p. 253- 265
The core pathogenic process in the common marmoset model of multiple sclerosis (MS) is the activation of memory-like T cells specific for peptide 34 to 56 derived from the extracellular domain of myelin/oligodendrocyte glycoprotein (MOG 34-56). Immunization with MOG 34-56 in incomplete Freund's adjuvant is a sufficient stimulus for in vivo activation of these T cells, together with the induction of MS-like disease and CNS pathology. Ex vivo functional characteristics of MOG 34-56 specific T cells are specific cytolysis of peptide pulsed target cells and high IL-17A production. To indentify possible functions in this new model of T helper 1 cells, which play a central pathogenic role in MS models induced with complete Freund's adjuvant, we tested the effect of human interferon-γ (IFNγ) administration during disease initiation of the disease (day 0-25) and around the time of disease expression (psd 56-81). The results show a clear modulatory effect of early IFNγ treatment on humoral and cellular autoimmune parameters, but no generalized mitigating effect on the disease course. These results argue against a prominent pathogenic role of T helper 1 cells in this new marmoset EAE model.
|Common marmoset, IL-17, Interferon-gamma, Multiple sclerosis, Myelin/oligodendrocyte glycoprotein, T helper 1|
|Journal of Neuroimmune Pharmacology|
Jagessar, S.A, Gran, B, Heijmans, N, Bauer, J, Laman, J.D, 't Hart, B.A, & Constantinescu, C.S. (2012). Discrepant effects of human interferon-gamma on clinical and immunological disease parameters in a novel marmoset model for multiple sclerosis. Journal of Neuroimmune Pharmacology, 7(1), 253–265. doi:10.1007/s11481-011-9320-5