Structure and function of GC79/TRPS1, a novel androgen-repressible apoptosis gene
Expression of death-signaling genes induces many biochemical cascades resulting in elimination of cells via apoptosis or programmed cell death. GC79/TRPS1 is a novel apoptosis associated gene that encodes a multi-type zinc finger GATA-type transcription factor. Expression of GC79/TRPS1 is repressed in the rat ventral prostate and significantly elevated after androgen withdrawal by castration. Castration leads to regression of the prostate caused by apoptosis of androgen-dependent prostate cells. Prostate cancer consists of androgen-dependent and androgen-independent cells. The androgen-independent cells, usually present in the prostate of advanced prostate cancer patients do not have the ability to undergo apoptosis after androgen withdrawal. GC79/TRPS1 expression in androgen-dependent prostate cancer cells is repressed by androgens, while GC79/TRPS1 expression is hardly detectable in androgen-independent prostate cancer cells under cell culture conditions. This suggests that lack of GC79/TRPS1 expression could be a mechanism for the inability to induce the apoptotic pathway in androgen-independent prostate cancer cells after androgen withdrawal. This review will focus on the current knowlegde of the structure and function of GC79/TRPS1, a novel androgen-repressible apoptosis gene.
|Keywords||Androgen-independent, Apoptosis, GC79/TRPS1, Prostate cancer, Zinc finger protein|
|Persistent URL||dx.doi.org/10.1023/A:1013504710343, hdl.handle.net/1765/61667|
Chang, G.T.G, van den Bemd, G.J.C.M, Jhamai, M, & Brinkmann, A.O. (2002). Structure and function of GC79/TRPS1, a novel androgen-repressible apoptosis gene. Apoptosis, 7(1), 13–21. doi:10.1023/A:1013504710343