Outcome of BRCA1- compared with BRCA2-associated ovarian cancer: A nationwide study in the Netherlands
Annals of Oncology , Volume 24 - Issue 8 p. 2036- 2042
Background: Recent studies suggested an improved overall survival (OS) for BRCA2- versus BRCA1-associated epithelial ovarian cancer (EOC), whereas the impact of chemotherapy is not yet clear. In a nationwide cohort, we examined the results of primary treatment, progression-free survival (PFS), treatment-free interval (TFI), and OS of BRCA1 versus BRCA2 EOC patients. Methods: Two hundred and forty-five BRCA1- and 99 BRCA2-associated EOC patients were identified through all Dutch university hospitals. Analyses were carried out with the Pearson's Chi-square test, Kaplan-Meier, and Cox regression methods. Results: BRCA1 patients were younger at EOC diagnosis than BRCA2 patients (51 versus 55 years; P < 0.001), without differences regarding histology, tumor grade, and International Federation of Gynecology and Obstetrics (FIGO) stage. Complete response rates after primary treatment, including chemotherapy, did not differ between BRCA1 (86%) and BRCA2 patients (90%). BRCA1 versus BRCA2 patients had a shorter PFS (median 2.2 versus 3.9 years, respectively; P = 0.006), TFI (median 1.7 versus 2.8 years; P = 0.009), and OS (median 6.0 versus 9.7 years; P = 0.04). Differences could not be explained by age at diagnosis, FIGO stage or type of treatment. Conclusions: PFS and OS were substantially longer in BRCA2- than in BRCA1-associated EOC patients. While response rates after primary treatment were similarly high in both groups, TFI, as surrogate for chemosensitivity, was significantly longer in BRCA2 patients.
|BRCA1, BRCA2, Chemotherapy, Ovarian cancer, Response, Survival|
|Annals of Oncology|
|Organisation||Department of Gynaecology & Obstetrics|
Vencken, P.M.L.H, Reitsma, W, Kriege, M, Mourits, M.J, de Bock, G.H, de Hullu, J.A, … Seynaeve, C.M. (2013). Outcome of BRCA1- compared with BRCA2-associated ovarian cancer: A nationwide study in the Netherlands. Annals of Oncology, 24(8), 2036–2042. doi:10.1093/annonc/mdt068