Idiopathic infantile arterial calcification (IIAC) is a rare disease characterised by extensive depositions of hydroxyapatite in the internal elastic lamina of medium-sized and large arteries, frequently accompanied by periarticular calcifications. We report on three patients with various presenting signs and symptoms. Diagnostic imaging techniques and therapy with bisphosphonates will be discussed. For the first time long-term follow-up of up to 25 years will be reported.

Bisphosphonates, Diagnostics, Idiopathic infantile arterial calcification, Long-term follow-up, Therapy
dx.doi.org/10.1007/s00431-006-0146-8, hdl.handle.net/1765/61745
European Journal of Pediatrics
Erasmus MC: University Medical Center Rotterdam

van der Sluis, I.M, Boot, A.M, Vernooij, M.W, Meradji, M, & Kroon, A.A. (2006). Idiopathic infantile arterial calcification: Clinical presentation, therapy and long-term follow-up. European Journal of Pediatrics, 165(9), 590–593. doi:10.1007/s00431-006-0146-8