RATIONALE AND OBJECTIVES. TO understand normal bone development, studies in healthy children and adolescents are important. To assess the applicability of tibial quantitative ultrasound measurements (QUS) in children, we performed a study that compared dual-energy x-ray absorptiometry (DXA) of the lumbar spine and whole body with tibial QUS. METHODS. For this study we recruited 146 Dutch children and adolescents, 58 boys (median age, 14.1 years; range, 7.6-23.4 years) and 88 girls (median age, 18.0 years; range, 7.6-23.5 years). Tanner stage, weight, and height were assessed for all participants. Bone mineral density (BMD; g·cm -2) of the whole body and lumbar spine (L 2-L 4) and bone mineral apparent density (BMAD) of the lumbar spine (g·cm -3) were assessed by using the Lunar DPXL. For tibial QUS, the Soundscan compact system was used. RESULTS. Both lumbar as well as whole-body BMD showed a strong, significant correlation with tibial QUS in boys and girls: r(total body boys) = 0.81, r(total body girls) = 0.77, r(lumbar spine boys) = 0.79, and r(lumbar spine girls) = 0.72. Lumbar spine BMAD also showed significant correlations with tibial QUS: r(boys) = 0.63 and r(girls) = 0.63 (for all correlations, P < 0.001). CONCLUSIONS. Our study showing strong, significant correlations between DXA and tibial QUS measurements suggests that tibial QUS is a technique that may be applicable in children and adolescents.

Adolescent, Bone development, DXA, Pediatric, Tibial QUS
dx.doi.org/10.1097/00004424-200009000-00005, hdl.handle.net/1765/61814
Investigative Radiology: a journal of clinical and laboratory research
Erasmus MC: University Medical Center Rotterdam

van Rijn, R.R, van der Sluis, I.M, Lequin, M.H, Robben, S.G.F, de Muinck Keizer-Schrama, S.M.P.F, Hop, W.C.J, & van Kuijk, C. (2000). Tibial quantitative ultrasound versus whole-body and lumbar spine DXA in a Dutch pediatric and adolescent population. Investigative Radiology: a journal of clinical and laboratory research, 35(9), 548–552. doi:10.1097/00004424-200009000-00005