Objective: To compare the incidence and severity of pregnancy-induced hypertensive disorders in twin pregnancy and in singleton gestation. Study design: Case-control study in the setting of a University Hospital. Each pregnancy of a consecutive series of 187 twin pregnancies attending the antenatal clinic and booked before a gestational age of 24 weeks was matched for maternal age, parity, and gestational age at delivery with a singleton pregnancy delivered in the same year. Primary end points of the analysis of the course and outcome of pregnancy were pregnancy-induced hypertension and proteinuric pre-eclampsi. Results: In the twin pregnancy group, 21% of patients met the criteria for the diagnosis of a pregnancy-induced hypertensive disorder, compared with 13% in the singleton pregnancy group (P < 0.05). The difference was due to a significantly higher incidence of pregnancy-induced hypertension in twin (15%) than in singleton (6%) pregnancy (P < 0.05), in particular in nulliparous women. The incidence of pre-eclampsia was similar in twin (6%) and singleton pregnancies (6.5%), without a difference in severity and in the occurrence of the HELLP syndrome. Conclusion: The incidence of non-proteinuric pregnancy-induced hypertension, but not of proteinuric pre-eclampsia, is increased in twin pregnancy.

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doi.org/10.1016/0028-2243(94)01982-D, hdl.handle.net/1765/61934
European Journal of Obstetrics Gynecology and Reproductive Biology
Department of Gynaecology & Obstetrics

Santema, J.G, Koppelaar, E, & Wallenburg, H.C.S. (1995). Hypertensive disorders in twin pregnancy. European Journal of Obstetrics Gynecology and Reproductive Biology, 58(1), 9–13. doi:10.1016/0028-2243(94)01982-D