PURPOSE: To assess the effect of aging on the proportions of choline (Cho), creatine, and N-acetylaspartate (NAA) in the brains of elderly women and men. MATERIALS AND METHODS: A transverse plane above the ventricle of the brain was mapped with magnetic resonance spectroscopy. Examinations were performed in 1995-1996 with 271 healthy subjects (age range, 60-90 years; mean age, 73 years) and were repeated 4 years later (1999-2000). Student t tests were used for statistical analysis. RESULTS: Difference analysis of the changes in 4 years (paired data) reproduced the decrease in Cho in women only (2.9% per year, P < .001) that had been indicated with intersubject correlation analyses. Decreases in NAA, though significant in both men and women according to age correlation analyses (P < .01 for both), did not reach significance. The resulting sex difference in the Cho/NAA ratio at a mean age of 77 years, while not yet significant at a mean age of 73 years, was especially manifest in the posterior half of the plane analyzed. CONCLUSION: Increasing sex differences in Cho/NAA ratios in a supraventricular plane indicate that brain metabolite levels differ between women and men at advanced age.

Aging, Brain, Magnetic resonance (MR), Metabolism, Spectroscopy
dx.doi.org/10.1148/radiol.2263011937, hdl.handle.net/1765/61964
Erasmus MC: University Medical Center Rotterdam

Sijens, P.E, den Heijer, T, Origgi, D, Vermeer, S.E, Breteler, M.M.B, Hofman, A, & Oudkerk, M. (2003). Brain changes with aging: MR spectroscopy at supraventricular plane shows differences between women and men. Radiology, 226(3), 889–896. doi:10.1148/radiol.2263011937