Objectives: The aim of this study was to assess the vitamin D status in patients with occlusive or aneurysmatic arterial disease in relation to clinical cardiovascular risk profiles and markers of atherosclerotic disease. Methods: We included 490 patients with symptomatic peripheral arterial disease (PAD, n = 254) or aortic aneurysm (n = 236). Cardiovascular risk factors and comorbidities carotid intima-media thickness (CIMT), ankle-brachial index (ABI), serum high-sensitive C-reactive protein (hs-CRP) and vitamin D were assessed. Patients were categorised into severely (≤25 nmol l -1) or moderately (26-50 nmol l -1) vitamin D deficient, vitamin D insufficient (51-75 nmol l -1) or vitamin D sufficient (>75 nmol l -1). Results: Overall, 45% of patients suffered from moderate or severe vitamin D deficiency. The prevalence of vitamin D deficiency was similar in patients with PAD and those with an aortic aneurysm. Low levels of vitamin D were associated with congestive heart failure and cerebrovascular disease. Adjusting for clinical cardiovascular risk factors, multivariable regression analyses showed that low vitamin D status was associated with higher CIMT (P = 0.001), lower ABI (P < 0.001) and higher hs-CRP (P = 0.022). Conclusions: The current study shows a strong association between low vitamin D status and arterial disease, independent of traditional cardiovascular risk factors and irrespective of the type of vascular disease, that is, occlusive or aneurysmatic disease.

, , ,
doi.org/10.1016/j.ejvs.2012.06.017, hdl.handle.net/1765/62075
European Journal of Vascular and Endovascular Surgery
Department of Surgery

van de Luijtgaarden, K.M, Voûte, M.T, Hoeks, S.E, Bakker, E.J, Chonchol, M, Stolker, R.J, … Verhagen, H.J.M. (2012). Vitamin D deficiency may be an independent risk factor for arterial disease. European Journal of Vascular and Endovascular Surgery, 44(3), 301–306. doi:10.1016/j.ejvs.2012.06.017