Effects of cerebral air embolism on brain metabolism in pigs
Acta Neurologica Scandinavica , Volume 108 - Issue 2 p. 118- 124
Objectives - Cerebral air embolism was induced in pigs and changes in intracranial pressure (ICP), brain oxygen (PbrO2), brain carbon dioxide (PbrCO2), brain pH (brpH) and glucose, lactate and pyruvate levels were used to characterize this model. Methods - In seven anesthetized pigs, ICP, PbrO2, PbrCO2 and brpH were measured continuously with multiparameter sensors and brain glucose metabolism by microdialysis. Alter injection of air into the internal carotid artery, these parameters were recorded for 2 h. Results - ICP increased (433%) from 12 ± 1 to 52 ± 8 mmHg (P < 0.05). PbrO2 decreased from 25.7 ± 6.2 to 11.9 ± 5.2 mmHg. PbrCO2 increased (109%) from 57.7 ± 2.7 to 120.4 ± 21.5 mmHg (P < 0.05). Brain glucose decreased (38%) from 3.05 ± 0.91 to 1.91 ± 0.55 mmol, while brain lactate increased (384%) from 1.36 ± 0.15 to 5.22 ± 0.53 mmol/l (P < 0.05). Conclusions - Cerebral air embolism has a deleterious effect on ICP and brain metabolism. Therefore, this model may be suitable for testing therapeutic regimens in cerebral air embolism.
|Air embolism, Brain metabolism, Intracranial pressure, Microdialysis, Multiparameter sensor|
|Acta Neurologica Scandinavica|
|Organisation||Department of Anesthesiology|
van Hulst, R.A, Lameris, Th.W, Hasan, D, Klein, J, & Lachmann, B.F. (2003). Effects of cerebral air embolism on brain metabolism in pigs. Acta Neurologica Scandinavica, 108(2), 118–124. doi:10.1034/j.1600-0404.2003.00100.x