Antioxidants prevent oxidative stress that possibly causes neuronal loss in Alzheimer's disease (AD). We examined whether high plasma levels of the antioxidant vitamins A and E were associated with lower prevalence of AD or cognitive decline (CD). We performed a crosssectional study within the Rotterdam Study. In an univariate model, higher levels of vitamins A and E were significantly associated with lower prevalence of AD. However, when additional adjustments were made for important confounders, such as age, gender and total cholesterol, the relation substantially weakened - odds ratios per standard deviation increase were 0.87 (95% CI 0.64-1.19) for vitamin A and 0.94 (95% CI 0.60-1.48) for vitamin E. Antioxidants were not related to CD in non-demented subjects. Our findings suggest no association between plasma levels of vitamin A and E and AD or CD. Copyright

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Dementia and Geriatric Cognitive Disorders
Department of Neurology

Engelhart, M.J, Ruitenberg, A, Meijer, J, Kiliaan, A.J, van Swieten, J.C, Hofman, A, … Breteler, M.M.B. (2005). Plasma levels of antioxidants are not associated with Alzheimer's disease or cognitive decline: A population-based study. Dementia and Geriatric Cognitive Disorders, 19(2-3), 134–139. doi:10.1159/000082884