Grey scale intravascular ultrasound (IVUS) is a valuable clinical tool to assess the extent and severity of coronary atheroma. However, it cannot reliably identify plaques with a high-risk of future clinical events. Serial IVUS studies to assess the progression and/or regression of atherosclerotic plaques demonstrated only modest effects, of pharmacological intervention on plaque burden, even when clinical efficacy is documented. Spectral analysis of radiofrequency ultrasound data (IVUS-virtual histology™ (IVUS-VH), Volcano Therapeutics, Rancho Cordova, CA) has the potential to characterize accurately plaque composition. The Integrated Biomarker and Imaging Study (IBIS) evaluated both invasive and non-invasive imaging techniques along with the assessment of novel biomarkers to characterize sub-clinical atherosclerosis. IVUS-VH was not included at the start of the IBIS protocol. The purpose of this paper is to describe the methodology we used to obtain and analyse IVUS-VH images and the approach to cross-correlations with the other techniques.

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International Journal of Cardiovascular Interventions
Erasmus MC: University Medical Center Rotterdam

Rodriguez-Granillo, G.A, Aoki, J, Ong, A.T.L, Valgimigli, M, van Mieghem, C.A.G, Regar, E.S, … Serruys, P.W.J.C. (2005). Methodological considerations and approach to cross-technique comparisons using in vivo coronary plaque characterization based on intravascular ultrasound radiofrequency data analysis: Insights from the Integrated Biomarker and Imaging Study (IBIS). International Journal of Cardiovascular Interventions, 7(1), 52–58. doi:10.1080/14628840410030559