Comparison of Peripheral and Central Schizophrenia Biomarker Profiles
PLoS ONE , Volume 7 - Issue 10
We have recently shown that a molecular biomarker signature comprised of inflammatory, hormonal and growth factors occurs in the blood serum from first onset schizophrenia patients. Here, we use the same platform to investigate post mortem brain tissue (Brodmann area 10) from schizophrenia patients who were mainly chronically ill and drug treated. Twenty-one analytes are differentially expressed in post-mortem brain tissue. Comparison with our previous mRNA profiling studies of the same patient samples in another frontal cortical area showed that 9 of these molecules were also altered at the transcriptional level. Furthermore, 9 of the molecules were also altered in serum from living first onset schizophrenia patients compared to controls. We propose a model in which the brain and periphery are coordinated through hormones and other regulatory molecules released into the blood via the diffuse neuroendocrine system. These findings provide further evidence for the systemic nature of schizophrenia and give added validity to the concept that schizophrenia can be investigated through studies of blood-based biomarkers.
|This work was funded by the European Commission 7th Framework Programme; grant id fp7/223427 - Developing minimally invasive, tools and technologies for high throughput, low cost molecular assays for the early diagnosis of schizophrenia and other psychiatric disorders (SCHIZDX)|
|Organisation||Department of Neuroscience|
Harris, L.W, Pietsch, S, Cheng, T.M.K, Schwarz, E, Guest, P.C, & Bahn, S. (2012). Comparison of Peripheral and Central Schizophrenia Biomarker Profiles. PLoS ONE, 7(10). doi:10.1371/journal.pone.0046368