The polymorphic minor histocompatibility antigen HA-1 induces powerful T-cell alloreactivities with important consequences for graft-vs-tumor activity and development of graft-vs-host disease in patients after human leukocyte antigen-matched stem-cell transplantation (SCT). In view of possible translational animal studies, we analyzed the evolutionary conservation of the diallelic HA-1 locus in four mammalian species. Our results show that rodents do not encode the HA-1H allele, neither show polymorphism in this position on the HA-1 gene. Contrariwise, the HA-1H allele is present in non-human primate species and dogs. Interestingly, both the HA-1H T-cell epitope and its non-immunogenic counterpart HA-1R are present in the latter species. Thus, the HA-1 allelic polymorphism is conserved in evolution in primates and dogs.

Evolution, Minor histocompatibility antigen HA-1, Single nucleotide polymorphism, T cell epitope,
Tissue Antigens
Department of Immunology

Wieles, B, Pool, J, Wilke, M, Weber, M, Kolb, H.-J, Bontrop, R.E, & Goulmy, E. (2006). The diallelic locus encoding the minor histocompatibility antigen HA-1 is evolutionarily conserved. Tissue Antigens, 68(1), 62–65. doi:10.1111/j.1399-0039.2006.00603.x