Treatment of operable breast cancer in the elderly: A randomised clinical trial EORTC 10851 comparing tamoxifen alone with modified radical mastectomy
European Journal of Cancer , Volume 39 - Issue 3 p. 309- 316
For treatment of early breast cancer in older women, little evidence is available from randomised trials. We conducted a randomised trial comparing modified radical mastectomy (MRM) with tamoxifen (TAM) as the sole initial therapy in 164 patients aged ≥70 years with operable breast cancer. 82 were treated by MRM and 82 with TAM. Survival curves were estimated using the Kaplan-Meier method: multivariate analyses were performed using the Cox's proportional hazards model. Endpoints included survival, time to first relapse or progression, loco-regional progression, time to distant progression and progression-free survival. After a median follow-up of approximately 10 years, there was a significantly decreased time to progression in the TAM only group (logrank P<0.0001) and significantly shorter time to local progression within the TAM group (logrank P<0.0001). Overall survival of the two groups was similar. The results indicate that tamoxifen alone leads to an unacceptably high rate of local progression or relapse.
|Breast cancer, Elderly, Mastectomy, Randomised trial, Tamoxifen|
|European Journal of Cancer|
|Organisation||Department of Surgery|
Fentiman, I.S, Christiaens, M.R, Paridaens, R, van Geel, A.N, Rutgers, E.J.T, Berner, J, … Therasse, P. (2003). Treatment of operable breast cancer in the elderly: A randomised clinical trial EORTC 10851 comparing tamoxifen alone with modified radical mastectomy. European Journal of Cancer, 39(3), 309–316. doi:10.1016/S0959-8049(02)00673-1