To increase awareness of the possible coexistence of an ovarian and breast carcinoma in a BRCA1 mutation carrier, we describe a patient with primary ovarian cancer who developed distant metastases after 3 years and again after 6 years. Surprisingly, at that time an occult breast carcinoma was identified to be the origin of the 2 metastatic locations as confirmed by molecular analysis. Eventually the patient could be treated accordingly.

BRCA1/2 mutation (carrier), Breast cancer, Molecular analysis, Ovarian cancer,
Human Pathology
Department of Pathology

Kuenen-Boumeester, V, den Bakker, M.A, Dinjens, W.N.M, & Seynaeve, C.M. (2004). A metastasis of an adenocarcinoma in a BRCA1 mutation carrier, a diagnostic problem not solved by morphology alone. Human Pathology, 35(5), 629–632. doi:10.1016/j.humpath.2003.11.008