Background: In patients on chronic hemodialysis leukocyte activation has been related to the impaired function of the immune system. In this study we investigated if the vitamin E-coated dialyzer membrane could reduce monocyte activation thereby improving cellular immunity. Methods: This hypothesis was tested in a prospective crossover trial in which 14 stable hemodialysis patients were switched from the baseline hemophane dialyzer to a vitamin E-coated and thereafter a polysulphone dialyzer membrane or vice versa. Results: Monocyte MHC class I, CD54 and ICAM-1 expression was significantly downregulated when a vitamin E-coated or polysulphone dialyzer was used. The use of a vitamin E membrane specifically decreased monocyte CD40 and CD86 expression. Lectin induced T cell proliferation increased with the use of the vitamin E-coated membrane as compared to polysulphone and hemophane dialyzers. Conclusion: Vitamin E-coated dialyzers induced a lessactivated phenotype of monocytes and may improve cellular immunity. Copyright

Additional Metadata
Keywords Antigen presentation, Biocompatibility, Hemodialysis, Monocyte, Vitamin E
Persistent URL dx.doi.org/10.1159/000082042, hdl.handle.net/1765/62689
Journal Blood Purification
Citation
Betjes, M.G.H, Hoekstra, F.M.E, Klepper, M, Postma, S, & Vaessen, L.M.B. (2004). Vitamin E-coated dialyzer membranes downregulate expression of monocyte adhesion and co-stimulatory molecules. Blood Purification, 22(6), 510–517. doi:10.1159/000082042