Leukaemia in neonates (infants <1 month) is rare, whereby neonatal acute myeloid leukaemia (AML) is more frequent than neonatal acute lymphoblastic leukaemia (ALL). High mortality rates are observed, though AML has a better prognosis than ALL. Neonatal leukaemia is typically presented with hepatosplenomegaly, leukaemia cutis and/or hyperleucocytosis. Congenital infections should be ruled out before diagnosis. Rearrangement of the . MLL gene is the most frequently occurring genetic aberration. Treatment includes intensive multi-agent chemotherapy, usually with age-related dose adjustments next to supportive care. Treatment intensification for ALL could be indicated in the future as the dismal prognosis is subject to high relapse rates in ALL.

Acute lymphoblastic leukaemia, Acute myeloid leukaemia, Mixed lineage leukaemia, Neonate
dx.doi.org/10.1016/j.siny.2012.03.003, hdl.handle.net/1765/62741
Seminars in Fetal & Neonatal Medicine
Erasmus MC: University Medical Center Rotterdam

van der Linden, M.H, Creemers, S.G, & Pieters, R. (2012). Diagnosis and management of neonatal leukaemia. Seminars in Fetal & Neonatal Medicine (Vol. 17, pp. 192–195). doi:10.1016/j.siny.2012.03.003