The impact of guideline compliant medical therapy on clinical outcome in patients with stable angina: Findings from the Euro Heart Survey of stable angina
Aims: The European Society of Cardiology published guidelines for the management of stable angina in 1997, with the objective of promoting an evidence-based approach to the condition. This study focuses on the impact of guideline compliant medical treatment on clinical outcome in patients with stable angina. Methods and results: The Euro Heart Survey of Stable Angina is a multicentre prospective observational study conducted between 2002 and 2003. Patients with a clinical diagnosis of stable angina by a cardiologist were enrolled and follow-up was conducted at 1 year. The primary outcome of interest was death or myocardial infarction (MI). The increasing intensity of guideline compliant medical therapy was quantified by means of a simple treatment score based on the use of guideline advocated therapies: antiplatelets, statins, and beta-blockers. A total of 3779 patients were included in the initial survey. Increasing intensity of guideline compliant therapy at initial assessment was associated with a reduction in death and MI during follow-up in patients with angina and confirmed coronary disease (HR 0.68; 95% CI 0.49-0.95 per unit increase in treatment score). All cardiovascular events were also significantly reduced in this subgroup (HR 0.82; 95% CI 0.69-0.97). The benefits of guideline compliant therapy were only observed in patients with objective evidence of coronary disease. Conclusion: Guideline compliant medical therapy improves clinical outcome in patients with stable angina and objective evidence of coronary disease.
|Keywords||Evidence based therapy, Guideline compliance, Prognosis, Secondary prevention|
|Persistent URL||dx.doi.org/10.1093/eurheartj/ehl005, hdl.handle.net/1765/62969|
|Journal||European Heart Journal|
Daly, C.A, Clemens, P.R, Lopez-Sendon, J, Tavazzi, L, Boersma, H, Danchin, N, … Fox, K. (2006). The impact of guideline compliant medical therapy on clinical outcome in patients with stable angina: Findings from the Euro Heart Survey of stable angina. European Heart Journal, 27(11), 1298–1304. doi:10.1093/eurheartj/ehl005