DNA replication is a fragile process, since unavoidable lesions in the template DNA cause replicative polymerases to stall, posing a serious threat to genome integrity. Homologous recombination, translesion DNA synthesis and de novo reinitiation of DNA synthesis ensure robust replication by navigating it passed damaged DNA. In this review, we highlight the relationship between these three processes.

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doi.org/10.1016/j.yexcr.2006.06.011, hdl.handle.net/1765/62972
Experimental Cell Research: emphasizing molecular approaches to cell biology
Department of Radiation Oncology

Eppink, B, Wyman, C, & Kanaar, R. (2006). Multiple interlinked mechanisms to circumvent DNA replication roadblocks. Experimental Cell Research: emphasizing molecular approaches to cell biology (Vol. 312, pp. 2660–2665). doi:10.1016/j.yexcr.2006.06.011