2006-08-15
Multiple interlinked mechanisms to circumvent DNA replication roadblocks
Publication
Publication
Experimental Cell Research: emphasizing molecular approaches to cell biology , Volume 312 - Issue 14 p. 2660- 2665
DNA replication is a fragile process, since unavoidable lesions in the template DNA cause replicative polymerases to stall, posing a serious threat to genome integrity. Homologous recombination, translesion DNA synthesis and de novo reinitiation of DNA synthesis ensure robust replication by navigating it passed damaged DNA. In this review, we highlight the relationship between these three processes.
| Additional Metadata | |
|---|---|
| , , , , , , | |
| doi.org/10.1016/j.yexcr.2006.06.011, hdl.handle.net/1765/62972 | |
| Experimental Cell Research: emphasizing molecular approaches to cell biology | |
| Organisation | Department of Radiation Oncology |
|
Eppink, B., Wyman, C., & Kanaar, R. (2006). Multiple interlinked mechanisms to circumvent DNA replication roadblocks. Experimental Cell Research: emphasizing molecular approaches to cell biology (Vol. 312, pp. 2660–2665). doi:10.1016/j.yexcr.2006.06.011 |
|