In pediatric oncology, granulocyte colony-stimulating factor (G-CSF) is applied with the aim of shortening neutropenic periods after chemotherapy and for mobilization of peripheral blood stem cells for apheresis procedures. G-CSF is administered, subcutaneously or intravenously, on a daily basis. An insuflon device for the administration of G-CSF was used in 29 patients for 93 G-CSF periods. Retrospective evaluation shows that this administration route is feasible, safe and preferred by young children rather than by teenagers with cancer.

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Supportive Care in Cancer
Department of Pediatrics

de Jong, M, Carbière, T, & van den Heuvel-Eibrink, M.M. (2006). The use of an insuflon device for the administration of G-CSF in pediatric cancer patients. Supportive Care in Cancer, 14(1), 98–100. doi:10.1007/s00520-005-0872-x