Purpose: In a study to determine the effectiveness of ionizing radiation on the deterioration of visual acuity (VA) due to choroidal neovascularisation (CNV) the affected eyes of 10 patients were treated with a total dose of 24 Gy (6 Gy fractions). A special lenssparing technique was used to avoid cataract development. During 30 months of follow-up the visual acuity (VA) and scar size (SS) of the treated eyes and fellow eyes of all 10 patients were evaluated. Results: After 30 months of follow-up 5 eyes showed a stable VA and fluorescein angiogram (FA) appearance. Concerning 4 out of 5 eyes with progressive disease, the 4 eyes treated with radiation therapy had better VA and smaller SS as compared with the untreated fellow eyes with exudative AMD. Conclusions: The results suggest that 24 Gy either stabilizes or delays the deleterious effects of CNV on the visual acuity. Until now no late side effects have been observed.

age-related macular degeneration, radiation therapy, subfoveal choroidal neovascularization
dx.doi.org/10.1007/BF02583278, hdl.handle.net/1765/63027
Documenta Ophthalmologica
Department of Ophthalmology

Bergink, G.-J, Hoyng, C.B, van der Maazen, R.W, Deutman, A.F, & van Daal, W.A.J. (1996). Visual acuity and scar size in eyes with age-related subfoveal choroidal neovascular lesions, 30 months after radiation therapy. In Documenta Ophthalmologica (Vol. 92, pp. 61–75). doi:10.1007/BF02583278