An Immunological Basis for Chronic Histiocytic Intervillositis in Recurrent Fetal Loss
American Journal of Reproductive Immunology , Volume 70 - Issue 3 p. 230- 237
Problem: Chronic histiocytic intervillositis (CHIV) is a rare type of placental pathology that is associated with reproductive loss at all gestational ages. The aim of the study was to investigate the relationship between the severity of CHIV and the outcome of pregnancy and to compare the immune response between CHIV patients and controls to explore an immunological origin of CHIV.
Method of study: Microscopic slides were reviewed and scored according to a previously published grading system in 30 pregnancies of 22 CHIV patients. Partner-specific mixed lymphocyte reactions, cytotoxic T-lymphocyte precursor frequencies (CTLpf), and anti-HLA antibodies were determined in four patients and seven controls.
Results: Higher CHIV scores are associated with worse pregnancy outcome. CHIV patients demonstrated a higher CTLpf against their partner compared to non-complicated pregnancies (P = 0.03). The CTLpf was extremely high in 75% of the patients. Antipaternal HLA antibodies were only present in 75% of the CHIV patients compared to none of the controls (P = 0.02).
Conclusion: CHIV scores seem to be associated with the severity of adverse pregnancy outcome. High antipaternal cellular (T-cell) and humoral (B-cell) response to partner-specific CTLpf and the presence of anti-HLA antibodies directed to the partner suggest an immunologic origin of CHIV.
|Adverse pregnancy outcome, Chronic histiocytic intervillositis, Immunology, Miscarriage|
|American Journal of Reproductive Immunology|
|Organisation||Department of Pathology|
Reus, A.D, van Besouw, N.M, Molenaar, N.M, Steegers, E.A.P, Visser, W, de Kuiper, P, … Exalto, N. (2013). An Immunological Basis for Chronic Histiocytic Intervillositis in Recurrent Fetal Loss. American Journal of Reproductive Immunology, 70(3), 230–237. doi:10.1111/aji.12125