Acquired von Willebrand disease as a cause of recurrent mucocutaneous bleeding in primary thrombocythemia: Relationship with platelet count
Annals of Hematology , Volume 69 - Issue 2 p. 81- 84
We present a 4-year follow-up of a 42-year-old patient with primary thrombocythemia whose clinical course was complicated by two major mucocutaneous bleeding episodes. On both occasions an acquired functional von Willebrand factor deficiency was demonstrated. In contrast to what is reported in the literature, an inverse relationship between platelet number and plasma high-molecular-weight multimers of von Willebrand factor was established.
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|Annals of Hematology|
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van Genderen, P.J.J, Michiels, J.J, van der Poel-van de Luytgaarde, S.C, & van Vliet, H.H.D.M. (1994). Acquired von Willebrand disease as a cause of recurrent mucocutaneous bleeding in primary thrombocythemia: Relationship with platelet count. Annals of Hematology, 69(2), 81–84. doi:10.1007/BF01698487