2005-10-01
Hepatitis B immunoglobulins inhibit dendritic cells and T cells and protect against acute rejection after liver transplantation
Publication
Publication
American Journal of Transplantation , Volume 5 - Issue 10 p. 2393- 2402
The efficacy of anti-viral intravenous immunogobulins (anti-HBs Ig and anti-CMV Ig) in preventing acute rejection after liver transplantation was assessed in a retrospective analysis, and correlated to their effects on immune cells in vitro. HBs Ag-positive liver graft recipients (n = 40) treated prophylactically with anti-HBs Ig had a significantly lower incidence of acute rejection compared with recipients without viral hepatitis (n = 147) (12% vs. 34%; p = 0.012), while the incidence of rejection in HCV-positive recipients (n = 29) was similar to that in the control group. Treatment with anti-CMV Ig (n = 18) did not protect against rejection. In vitro, anti-HBs Ig suppressed functional maturation of and cytokine production by human blood-derived dendritic cells (DC) at concentrations similar to the serum concentrations reached during anti-HBs Ig treatment of liver graft recipients. In addition, anti-HBs Ig inhibited allo-antigen- and lectin-stimulated proliferation of peripheral T cells. Anti-CMV Ig suppressed functional DC-maturation and alloantigen-stimulated T-cell proliferation, but not lectin-driven T-cell proliferation. In conclusion, anti-HBs Ig protects against acute rejection after liver transplantation, probably by functional inhibition of the two principal immune cells involved in allograft rejection, DC and T cells. Copyright
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doi.org/10.1111/j.1600-6143.2005.01029.x, hdl.handle.net/1765/63412 | |
American Journal of Transplantation | |
Organisation | Department of Pathology |
Kwekkeboom, J., de Man, R., Metselaar, H., Tha-In, T., Tra, W., Hop, W., … Kusters, J. (2005). Hepatitis B immunoglobulins inhibit dendritic cells and T cells and protect against acute rejection after liver transplantation. American Journal of Transplantation, 5(10), 2393–2402. doi:10.1111/j.1600-6143.2005.01029.x |