2012-11-21
HIV-1 Clade D Is Associated with Increased Rates of CD4 Decline in a Kenyan Cohort
Publication
Publication
PLoS ONE , Volume 7 - Issue 11
HIV-1 is grouped phylogenetically into clades, which may impact rates of HIV-1 disease progression. Clade D infection in particular has been shown to be more pathogenic. Here we confirm in a Nairobi-based prospective female sex worker cohort (1985-2004) that Clade D (n = 54) is associated with a more rapid CD4 decline than clade A1 (n = 150, 20.6% vs 13.4% decline per year, 1.53-fold increase, p = 0.015). This was independent of "protective" HLA and country of origin (p = 0.053), which in turn were also independent predictors of the rate of CD4 decline (p = 0.026 and 0.005, respectively). These data confirm that clade D is more pathogenic than clade A1. The precise reason for this difference is currently unclear, and requires further study. This is first study to demonstrate difference in HIV-1 disease progression between clades while controlling for protective HLA alleles.
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| doi.org/10.1371/journal.pone.0049797, hdl.handle.net/1765/63423 | |
| PLoS ONE | |
| Organisation | Erasmus MC: University Medical Center Rotterdam |
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McKinnon, L., Nagelkerke, N., Kaul, R., Shaw, S., Capina, R., Luo, M., Kariri, A., Apidi, W., Kimani, M., Wachihi, C., Jaoko, W., Anzala, O., Kimani, J., Ball, B.& Plummer, F. (2012). HIV-1 Clade D Is Associated with Increased Rates of CD4 Decline in a Kenyan Cohort. PLoS ONE, 7(11).https://doi.org/10.1371/journal.pone.0049797 |
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