Paclitaxel eluting stents for the treatment of angiographically non-significant atherosclerotic lesions
International Journal of Cardiovascular Interventions , Volume 7 - Issue 2 p. 68- 71
OBJECTIVE: To assess the safety and efficacy of the implantation of Paclitaxel Eluting Stents (PES) for de novo, non-flow limiting lesions. METHODS AND RESULTS: We assessed the 12-month occurrence of major adverse cardiac events (MACE) in 21 patients (4% of the total population treated in a 'real world' registry) with 22 non-significant coronary narrowings treated with PES. The following criteria had to be met: (1) the lesion was de novo; (2) the location was non-ostial, and not a bifurcation lesion; (3) the diameter stenosis by quantitative coronary angiography (QCA) was < 50%; (4) there was no visible thrombus and (5) the lesion was not located in an angiographically diffusely diseased segment. Procedural success rate was 100% without any periprocedural myocardial infarction. After a mean follow-up of 407.33 ± 53 (range: 344-498) days the overall MACE-free survival was 95.2%. Freedom from target revascularization was 95.2%. CONCLUSIONS: The result of this non-randomized observational study suggests that the implantation of PES for de novo, non-significant lesions appears most probably safe and effective.
|Atherosclerosis, Local delivery, Moderate stenosis, Stent|
|International Journal of Cardiovascular Interventions|
|Organisation||Erasmus MC: University Medical Center Rotterdam|
Rodriguez-Granillo, G.A, Valgimigli, M, Ong, A.T.L, Aoki, J, van Mieghem, C.A.G, Hoye, A, … Serruys, P.W.J.C. (2005). Paclitaxel eluting stents for the treatment of angiographically non-significant atherosclerotic lesions. International Journal of Cardiovascular Interventions, 7(2), 68–71. doi:10.1080/14628840510011261