OBJECTIVE: To assess the safety and efficacy of the implantation of Paclitaxel Eluting Stents (PES) for de novo, non-flow limiting lesions. METHODS AND RESULTS: We assessed the 12-month occurrence of major adverse cardiac events (MACE) in 21 patients (4% of the total population treated in a 'real world' registry) with 22 non-significant coronary narrowings treated with PES. The following criteria had to be met: (1) the lesion was de novo; (2) the location was non-ostial, and not a bifurcation lesion; (3) the diameter stenosis by quantitative coronary angiography (QCA) was < 50%; (4) there was no visible thrombus and (5) the lesion was not located in an angiographically diffusely diseased segment. Procedural success rate was 100% without any periprocedural myocardial infarction. After a mean follow-up of 407.33 ± 53 (range: 344-498) days the overall MACE-free survival was 95.2%. Freedom from target revascularization was 95.2%. CONCLUSIONS: The result of this non-randomized observational study suggests that the implantation of PES for de novo, non-significant lesions appears most probably safe and effective.

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doi.org/10.1080/14628840510011261, hdl.handle.net/1765/63425
International Journal of Cardiovascular Interventions
Erasmus MC: University Medical Center Rotterdam

Rodriguez-Granillo, G., Valgimigli, M., Ong, A., Aoki, J., van Mieghem, C., Hoye, A., … Serruys, P. (2005). Paclitaxel eluting stents for the treatment of angiographically non-significant atherosclerotic lesions. International Journal of Cardiovascular Interventions, 7(2), 68–71. doi:10.1080/14628840510011261