Calcium sensitizer EMD 57033, but not the β1-adrenoreceptor agonist dobutamine, increases mechanical efficiency in stunned myocardium
Journal of Cardiovascular Pharmacology , Volume 39 - Issue 1 p. 61- 72
External work, efficiency of energy transfer (EET), and mechanical efficiency (defined as the ratio of external work over myocardial oxygen consumption (MVo2)are reduced in stunned myocardium. We therefore evaluated how inotropic stimulation by dobutamine and the calcium sensitizer EMD 57033 affected the regional stress-strain relationship as, from which contractility (Ees), external work at the working point (EWwp), maximal external work (EWmax), EETwp (%), and EETmax are determined. Thirty minutes after regional stunning in 11 open chest pigs by two 10-min coronary occlusions separated by 10 min of reperfusion, dobutamine (0.5, 1, and 2 μg × kg-1 × min-1) was infused, after an ample washout period followed by infusion of EMD 57033 (0.05, 0.1, 0.2 mg × kg-1 × min-1). Stunning decreased Ees (30%), EWwp (56%), EWmax (63%), EETwp (34%), EETmax (33%) and mechanical efficiency (55%), but MVo2 was unaffected. EWwp, EWmax, EETwp, and EETmax increased similarly with the two drugs, whereas MVo2 increased only after dobutamine. Consequently, mechanical efficiency increased linearly with contractility during EMD 57033 infusion but remained constant during infusion of dobutamine.
|Calcium sensitization, Dobutamine, EMD 57033, Energetics, Mechanical efficiency, Regional myocardial stunning|
|Journal of Cardiovascular Pharmacology|
|Organisation||Department of Neuroscience|
Trines, S.A, Smits, C.A.G, van der Moer, J, Slager, C.J, Verdouw, P.D, & Krams, R. (2002). Calcium sensitizer EMD 57033, but not the β1-adrenoreceptor agonist dobutamine, increases mechanical efficiency in stunned myocardium. Journal of Cardiovascular Pharmacology, 39(1), 61–72. doi:10.1097/00005344-200201000-00008