Prevalence of eight human herpesviruses (HHV1-8) was determined by real-time PCR in cell-rich cerebrospinal fluid (CSF) samples, obtained early after disease symptoms, of Dutch patients with multiple sclerosis (MS) and other noninfectious central nervous system diseases (NIND). Whereas HHV1-8 DNA was undetectable in CSF samples of MS patients, HHV6 DNA was detected in a plexus neuritis case and HHV7 DNA in an ependymoma and a Behçets' disease patient. However, intrathecal HHV infection was not detected. Data indicate that HHV1-8 are rarely detected in CSF of Dutch NIND patients and do not support the role of intrathecal HHV infection early after onset of disease symptoms in MS.

Cerebrospinal fluid, DNA and RNA, Human herpesviruses, Multiple sclerosis, Noninfectious neurological disease, Real-time PCR,
Journal of NeuroVirology
Department of Neurology

van Nierop, G.P, Hintzen, R.Q, & Verjans, G.M.G.M. (2014). Prevalence of human Herpesviridae in cerebrospinal fluid of patients with multiple sclerosis and noninfectious neurological disease in the Netherlands. Journal of NeuroVirology, 20(4), 412–418. doi:10.1007/s13365-014-0248-4