Background: The aim of this study was to develop a simple method for closure of a perforated peptic ulcer, making it more accessible for laparoscopic surgery. Methods: An experimental pilot study was performed using five male Wistar rats. The perforation was closed by a bioabsorbable patch made of lactide-glycolid-caprolactone fixed with glue onto the outside of the stomach. Results: Postoperatively, there were no signs of leakage or other complications. Histologically, there were no signs of inflammation on the inside of the stomach, and there was a 50% reduction of the perforation each successive postoperative week. No adverse reactions because of the degradable material or glue were observed. Conclusions: Treatment of a perforated peptic ulcer by placing a patch of biodegradable material like a "stamp" on the outside of the stomach is a feasible option.

Biodegradable patch, Glue, Laparoscopy, Perforated peptic ulcer
dx.doi.org/10.1007/s00464-004-2157-8, hdl.handle.net/1765/63573
Surgical Endoscopy: surgical and interventional techniques
Department of Surgery

Bertleff, M.J.O.E, Liem, R.S.B, Bartels, H.L, Robinson, P.H, van der Werff, J.F.A, Bonjer, H.J, & Lange, J.F. (2006). The "stamp method": A new treatment for perforated peptic ulcer?. Surgical Endoscopy: surgical and interventional techniques, 20(5), 791–793. doi:10.1007/s00464-004-2157-8