There is a need for information on the bioavailability in pediatric patients of drugs from manipulated dosage forms when applied in combination with food and/or co-medication under realistic daily practice circumstances. We describe the development, validation and application of a dynamic, computer-controlled in vitro system mimicking the conditions in the upper gastrointestinal tract of neonates, infants and toddlers: TIMpediatric. Paracetamol and diclofenac in age-related food matrices and with esomeprazole co-medication were tested. The experiments showed relevant results on the impact of drug manipulation and co-medication on the availability for absorption of active compounds. Without ethical constraints, alternative approaches for oral dosing and new pediatric formulations can be studied in TIMpediatric with a high predictive value.

Bioaccessibility, Drug handling, In vitro gastrointestinal model, Pediatric drug
dx.doi.org/10.1016/j.ijpharm.2013.07.053, hdl.handle.net/1765/63686
International Journal of Pharmaceutics
Erasmus MC: University Medical Center Rotterdam

Havenaar, R, Anneveld, B, Hanff, L.M, de Wildt, S.N, de Koning, B.A.E, Mooij, M.G, … Minekus, J. (2013). In vitro gastrointestinal model (TIM) with predictive power, even for infants and children?. International Journal of Pharmaceutics, 457(1), 327–332. doi:10.1016/j.ijpharm.2013.07.053