A hemolytic bystander assay was used to assess the functional serum mannose-binding lectin (MBL) activating capacity of five isolates of Moraxella catarrhalis obtained from children who suffered recurrent acute otitis media episodes. Results showed that this organism is only a poor activator of the lectin pathway of complement activation, with subsequent consequences for the etiology of otitis media by this organism.

Complement activation, Mannose-binding lectin, Moraxella catarrhalis
dx.doi.org/10.1016/j.femsle.2005.05.048, hdl.handle.net/1765/63776
F E M S Microbiology Letters
Department of Medical Microbiology and Infectious Diseases

Hays, J.P, Ott, A, Verduin, C.M, van Belkum, A.F, & Kuipers, S. (2005). Moraxella catarrhalis is only a weak activator of the mannose-binding lectin (MBL) pathway of complement activation. F E M S Microbiology Letters, 249(2), 207–209. doi:10.1016/j.femsle.2005.05.048