2004
Phosphorescence-Fluorescence ratio imaging for monitoring the oxygen status during photodynamic therapy
Publication
Publication
Optics Express , Volume 12 - Issue 9 p. 1873- 1878
The effectiveness of photodynamic therapy is strongly dependent on the availabilty of oxygen. In the present paper we show that the ratio between photosensitiser phosphorescence and fluorescence is a parameter that can be used to monitor the competition between singlet oxygen production and other processes quenching the photosensitiser triplet state. We present a theoretical basis for the validity of this approach and a series of in vitro imaging experiments.
| Additional Metadata | |
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| doi.org/10.1364/OPEX.12.001873, hdl.handle.net/1765/63905 | |
| Optics Express | |
| Organisation | Department of Radiation Oncology |
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Sterenborg, D., de Wolf, J., Koning, M., Kruijt, B., van der Ploeg-van den Heuvel, A., & Robinson, D. (2004). Phosphorescence-Fluorescence ratio imaging for monitoring the oxygen status during photodynamic therapy. Optics Express, 12(9), 1873–1878. doi:10.1364/OPEX.12.001873 |
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