Phosphorescence-Fluorescence ratio imaging for monitoring the oxygen status during photodynamic therapy
Optics Express , Volume 12 - Issue 9 p. 1873- 1878
The effectiveness of photodynamic therapy is strongly dependent on the availabilty of oxygen. In the present paper we show that the ratio between photosensitiser phosphorescence and fluorescence is a parameter that can be used to monitor the competition between singlet oxygen production and other processes quenching the photosensitiser triplet state. We present a theoretical basis for the validity of this approach and a series of in vitro imaging experiments.
|Organisation||Department of Radiation Oncology|
Sterenborg, H.J.C.M, de Wolf, J.W, Koning, M, Kruijt, B, van der Ploeg-van den Heuvel, A, & Robinson, D.J. (2004). Phosphorescence-Fluorescence ratio imaging for monitoring the oxygen status during photodynamic therapy. Optics Express, 12(9), 1873–1878. doi:10.1364/OPEX.12.001873