Objectives: In order to assess whether chest pain attributed to sumatriptan is associated with abnormalities on cardiac exercise testing, we performed a case-control study.Subjects: Cases were selected as consumers of sumatriptan who reported sumatriptan associated chest pain. A reference group was selected randomly from consumers of sumatriptan with the same GP as the case, who reported no chest pain after use of sumatriptan. If possible, controls were matched for age (within 5-year groups) and gender.Outcomes: In a total of 74 cases and 55 controls symptom-limited exercise tests were performed. Besides a small difference in age, there were no differences in basic characteristics between cases and controls. Three cases had ST-depression on ECG during exercise. However, none of the variables measured during exercise testing differed significantly between cases and controls.Conclusions: The prevalence of abnormal exercise tests in patients with sumatriptan-induced chest pain is low, and not statistically different from patients without chest pain after intake of sumatriptan. Routine performance of exercise testing in patients with sumatriptan-associated chest pain is not recommended. Copyright (C) 1998 Elsevier Science B.V.

Adverse drug reaction, Angina pectoris, Coronary vasospasm, Exercise testing, Sumatriptan
dx.doi.org/10.1016/S0300-2977(98)00097-7, hdl.handle.net/1765/63942
The Netherlands Journal of Medicine
Erasmus MC: University Medical Center Rotterdam

Ottervanger, J.P, Hoorntje, J.C.A, Valkenburg, H.A, Grobbee, D.E, & Stricker, B.H.Ch. (1998). Exercise testing in patients with chest pain to sumatriptan. The Netherlands Journal of Medicine, 53(6), 245–248. doi:10.1016/S0300-2977(98)00097-7