Semantic distinctions between "normal" aging, "pathological" aging (or age-related disease) and "premature" aging (otherwise known as segmental progeria) potentially confound important insights into the nature of each of the complex processes. Here we review a recent, unexpected discovery: the presence of longevity-associated characteristics typical of long-lived endocrine-mutant and dietary-restricted animals in short-lived progeroid mice. These data suggest that a subset of symptoms observed in premature aging, and possibly normal aging as well, may be indirect manifestations of a beneficial adaptive stress response to endogenous oxidative damage, rather than a detrimental result of the damage itself.

Adaptive stress response, Ageing, Base excision repair, DNA damage, Nucleotide excision repair, Progeria, SIRT6
dx.doi.org/10.1016/j.mad.2006.11.011, hdl.handle.net/1765/64026
Mechanisms of Ageing and Development
Department of Molecular Genetics

van de Ven, H.W.M, Andressoo, J.-O, Holcomb, V.B, Hasty, P, Suh, Y, van Steeg, H, … Mitchell, J.R. (2007). Extended longevity mechanisms in short-lived progeroid mice: Identification of a preservative stress response associated with successful aging. Mechanisms of Ageing and Development, 128(1), 58–63. doi:10.1016/j.mad.2006.11.011