Semantic distinctions between "normal" aging, "pathological" aging (or age-related disease) and "premature" aging (otherwise known as segmental progeria) potentially confound important insights into the nature of each of the complex processes. Here we review a recent, unexpected discovery: the presence of longevity-associated characteristics typical of long-lived endocrine-mutant and dietary-restricted animals in short-lived progeroid mice. These data suggest that a subset of symptoms observed in premature aging, and possibly normal aging as well, may be indirect manifestations of a beneficial adaptive stress response to endogenous oxidative damage, rather than a detrimental result of the damage itself.

Adaptive stress response, Ageing, Base excision repair, DNA damage, Nucleotide excision repair, Progeria, SIRT6,
Mechanisms of Ageing and Development
Department of Molecular Genetics

van de Ven, H.W.M, Andressoo, J.-O, Holcomb, V.B, Hasty, P, Suh, Y, van Steeg, H, … Mitchell, J.R. (2007). Extended longevity mechanisms in short-lived progeroid mice: Identification of a preservative stress response associated with successful aging. Mechanisms of Ageing and Development, 128(1), 58–63. doi:10.1016/j.mad.2006.11.011