The t(8;21) is perhaps the most frequent chromosomal translocation associated with acute myeloid leukemia. The translocation creates a fusion protein that consists of the DNA binding domain of the RUNX1 transcription factor fused to the MTG8 transcriptional co-repressor to create a potent transcriptional repressor. Here, we discuss the possibility that the t(8;21) fusion protein represses tumor suppressors that regulate the RAS signaling pathway and the p53 oncogenic checkpoint.

14ARF, ETO, MTG8, NF1, Ras, RUNX1
dx.doi.org/10.1007/s00277-003-0841-8, hdl.handle.net/1765/64129
Annals of Hematology
Department of Hematology

Yang, G, Khalaf, W, van de Locht, L, Jansen, J.H, van der Reijden, B.A, Müller-Tidow, C, … Hiebert, S.W. (2004). Epigenetic regulation of tumor suppressors in t(8:21)-containing AML. Annals of Hematology (Vol. 83, pp. 329–330). doi:10.1007/s00277-003-0841-8