The t(8;21) is perhaps the most frequent chromosomal translocation associated with acute myeloid leukemia. The translocation creates a fusion protein that consists of the DNA binding domain of the RUNX1 transcription factor fused to the MTG8 transcriptional co-repressor to create a potent transcriptional repressor. Here, we discuss the possibility that the t(8;21) fusion protein represses tumor suppressors that regulate the RAS signaling pathway and the p53 oncogenic checkpoint.

14ARF, ETO, MTG8, NF1, Ras, RUNX1,
Annals of Hematology
Department of Hematology

Yang, G, Khalaf, W, van de Locht, L, Jansen, J.H, van der Reijden, B.A, Müller-Tidow, C, … Hiebert, S.W. (2004). Epigenetic regulation of tumor suppressors in t(8:21)-containing AML. Annals of Hematology (Vol. 83, pp. 329–330). doi:10.1007/s00277-003-0841-8