The t(8;21) is perhaps the most frequent chromosomal translocation associated with acute myeloid leukemia. The translocation creates a fusion protein that consists of the DNA binding domain of the RUNX1 transcription factor fused to the MTG8 transcriptional co-repressor to create a potent transcriptional repressor. Here, we discuss the possibility that the t(8;21) fusion protein represses tumor suppressors that regulate the RAS signaling pathway and the p53 oncogenic checkpoint.

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Annals of Hematology
Department of Hematology

Yang, G., Khalaf, W., van de Locht, L., Jansen, J., van der Reijden, B., Müller-Tidow, C., … Hiebert, S. (2004). Epigenetic regulation of tumor suppressors in t(8:21)-containing AML. Annals of Hematology (Vol. 83, pp. 329–330). doi:10.1007/s00277-003-0841-8