Background & Aims: Acute perforations of the gastrointestinal tract are rare, severe complications of endoscopy that usually require surgical repair. Endoscopic repair of perforations would reduce the need for surgeries; we evaluated the efficacy and safety of endoscopic closure of acute perforations of the gastrointestinal tract by using a new clip device. Methods: We conducted a prospective, international, multicenter study of 36 consecutive patients (15 male) with acute iatrogenic perforations (5 esophageal, 6 gastric, 12 duodenal, and 13 colonic perforation). Endoscopic repair was performed by using the Over-the-Scope-Clip according to a standardized operating procedure. Primary end point was successful closure, which was determined as endoscopic successful closure without leakage (detected by water-soluble contrast x-ray analysis), and absence of adverse events within 30 days after the procedure. Results: Immediate closure was endoscopically successful in 33 patients (92%). One patient developed an esophageal perforation while the cap was introduced, and in 2 patients the perforations did not close; these 3 patients were successfully treated with surgery. None of the patients had leakage of soluble contrast on the basis of contrast x-ray. One patient with a closed colonic perforation deteriorated clinically within 6 hours after the procedure. Despite surgery, the patient died within 36 hours. The remaining 32 patients had successful endoluminal closures; the overall success rate was 89% (95% confidence interval, 75%-96%). The mean endoscopic closure time was 5 minutes 44 seconds ± 4 minutes 15 seconds. Conclusions: The Over-the-Scope-Clip is effective for endoluminal closure of acute iatrogenic perforations. It allows patients to avoid surgery, and 89% of patients had successful closures without adverse events.

Clinical Trial, Closure Technique, Complications, Endoscopy, Esophageal Perforation, Gastrointestinal, Humans, Intestinal Perforation, Natural Orifice Endoscopic Surgery, Surgical, Wound Closure Techniques
dx.doi.org/10.1016/j.cgh.2012.02.005, hdl.handle.net/1765/64333
Clinical Gastroenterology and Hepatology
Department of Gastroenterology & Hepatology

Voermans, R.P, Le Moine, O, von Renteln, D, Ponchon, T, Giovannini, M, Bruno, M.J, … Rösch, T. (2012). Efficacy of Endoscopic Closure of Acute Perforations of the Gastrointestinal Tract. Clinical Gastroenterology and Hepatology, 10(6), 603–608. doi:10.1016/j.cgh.2012.02.005