Neuroimmune alterations in the complex regional pain syndrome
European Journal of Pharmacology , Volume 429 - Issue 1-3 p. 101- 113
This review focuses on some clinical aspects of the complex regional pain syndrome, such as oedema, local temperature changes and chronic pain, as a result of supposed neurogenic inflammation. Involvement of the immune system could imply the subsequent release of neuropeptides, pro-inflammatory cytokines and eicosanoids, which in turn leads to a complex cross-talk of primary and secondary generated mediators of inflammation. The development and application of drugs that act through selective receptor antagonism or enzymatic synthesis inhibition to prevent further stimulation of this cascade that could inevitably lead to chronicity of this disease are extensively discussed.
|Complex regional pain syndrome, Cytokine, Eicosanoid, Neurogenic inflammation, Neuropeptide, Oedema, Pain, Temperature|
|European Journal of Pharmacology|
|Organisation||Department of Anesthesiology|
Huygen, F.J.P.M, de Bruijn, A.G.J, Klein, J, & Zijlstra, F.J. (2001). Neuroimmune alterations in the complex regional pain syndrome. European Journal of Pharmacology (Vol. 429, pp. 101–113). doi:10.1016/S0014-2999(01)01310-3