A randomised phase II study of 5-fluorouracil (5-FU) plus cisplatin (CDDP) with or without α-interferon 2b was performed in patients with pancreatic cancer with measurable metastatic disease outside the pancreas. The treatment in arm A consisted of cisplatin (100 mg/m 2) on day 1, followed by a continuous infusion of 5-FU 1000 mg/m 2 for 4 days and in arm B the same treatment was given plus α-interferon 2b in a dose of 3 million Units/day subcutaneously (s.c.) from day 1 for 5 days. 36 patients were entered in the trial, 18 in each arm. In arm B only 15 patients were eligible. No responses were observed in the 5-FU/CDDP arm and only 2 partial responses were achieved in the interferon-arm, lasting 27 and 32 weeks, respectively. Both treatment arms showed considerable toxicity. It has to be concluded that both treatment regimens have little activity and cannot be recommended.

Cisplatin plus 5-fluorouracil, Cisplatin plus 5-fluorouracil plus α-interferon, Pancreatic cancer, Phase II study
dx.doi.org/10.1016/S0959-8049(01)00319-7, hdl.handle.net/1765/64591
European Journal of Cancer
Department of Medical Oncology

Wagener, D.J.T, Wils, J.A, Kok, T, Planting, A.S.Th, Couvreur, M.L, & Baron, B. (2002). Results of a randomised phase II study of cisplatin plus 5-fluorouracil versus cisplatin plus 5-fluorouracil with α-interferon in metastatic pancreatic cancer: An EORTC gastrointestinal tract cancer group trial. European Journal of Cancer, 38(5), 648–653. doi:10.1016/S0959-8049(01)00319-7