The spike (S) protein of the recently emerged human Middle East respiratory syndromecoronavirus (MERS-CoV) mediates infection by binding to the cellular receptor dipeptidyl peptidase 4 (DPP4). Here we mapped the receptor binding domain in the S protein to a 231-amino-acid fragment (residues 358 to 588) by evaluating the interaction of spike truncation variants with receptor-expressing cells and soluble DPP4. Antibodies to this domain-mch less so those to the preceding N-terminal region-efficiently neutralize MERS-CoV infection.,
Journal of Virology
Department of Virology